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This leads to the release of numerous inflammatory factors and toxic substances into the surrounding microenvironment, threatening neuronal survival and resulting in impaired motor skills and behavioral changes observed in mouse behavioral tests [57]

Doxazosin attenuates liver fibrosis by inhibiting autophagy in hepatic stellate cells via activation of the PI3K/Akt/mTOR signaling pathway

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The wide regulation of the mitochondria in cancer is of great importance and is a promising target in the development of cancer therapy (73), a number of therapeutic strategies have been based on targeting tumor mitochondrial proteins and their functions, such as metformin that has had currently a lot of impact on cancer therapy (74)