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In an oxygen-glucose-deprivation/reperfusion injury paradigm, additionally, CBD has been shown to guard against energy stress on hippocampus neurons by controlling glucose uptake and triggering the pentose-phosphate pathway (95)

At present, several effective anti-tuberculosis drugs, such as isoniazid [55], ethionamide, thiacetazone, and delamanid, have been shown to inhibit the biosynthesis of MAs

By maintaining cellular health in the nervous system, it supports focus, memory, and overall cognitive resilience

These annotated proteins are involved in multiple cellular metabolic pathways, including DNA or RNA methylation, RNA processing, protein processing, lipid synthesis, membrane assembly, cell division, and cytoplasmic and membrane transfer steps of peptidoglycan synthesis, in which numerous metabolic pathways are closely related to the pathogenicity of Mtb

As discussed, due to the negative effects of nCDs and GCC on world economy, future studies should seek to develop strategies that may improve the bioavailability, mode of action, and pharmacokinetics properties of PPs in the cornerstone of AFs-induced nCDs treatment