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Similar results were obtained in HeLa cells, showing that GSK3 activity is required across different cell types (Appendix Fig

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In contrast, clientized S carrying the Thr1273Glu mutation became sequestered in early secretory compartments and did not reach the PM (Fig

As an effector molecule, NO participates in antimicrobial responses and cooperates with oxidative stress processes to amplify inflammatory signaling, thereby being associated with an M1-like pro-inflammatory program ( + macrophage-like state with immunoregulatory features in mouse macrophage models ( In addition to generating terminal effector molecules, Arg metabolism can also influence inflammatory transcriptional programs through metabolic-signaling coupling