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Surprisingly, inhibition of GSH synthesis by BSO was unable to change the distribution of cellular GSH, showing a cellular glutathione pattern different from the one shown in the DEM-treated cells

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Lastly, we observed that alcohol binges increased APP expression as well as the components of the molecular machinery involved in APP processing (beta-secretase 1, a disintegrin and metalloprotease 10) and A clearance (low-density lipoprotein receptor-related protein 1, insulin-degrading enzyme) compared to that of water-treated APP/PS1 mice indicating increased turnover of A