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Therefore, all Local Government Units (LGU) and Law Enforcement Agencies (LEAs), after the issuance of this advisory, are requested to ensure that this falsified drug product is not sold or not administered to patients in their localities or areas of jurisdiction

Furthermore, SFN may activate Nrf2 by initiating the transcription of trigger receptor expressed on myeloid cells-2 (TREM2) in the medial PFC (mPFC), increasing the expression of the M2 microglial marker arginase 1 (ARG1), which may alleviate depressive phenotypes through its anti-inflammatory and neuroprotective functions (He et al., 2022)