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Inhibition of Exo70, an Exocyst Complex Component, Enhances mRNA Delivery Efficiency of Lipid Nanoparticle Ha and Yong Main findings: Co-treatment of mRNA/LNP with Exo70 inhibitor enhances mRNA delivery efficiency in cell lines In vivo results demonstrate mRNA delivery in combination with Exo70 inhibitor highly improves mRNA delivery efficiency Implications: Exocytosis has been recognized as a obstacle for mRNA/LNP delivery This study demonstrates that the inhibition of Exo70, a component of exocyst complex, could be a novel strategy to improve mRNA delivery of LNP system To view or add a comment, sign in Clinical Fact Of The Day Did You Know Macular Degeneration Treatment May Soon Swap Monthly Eye Injections for Simple, Needle-Free Eye Drops

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Although formal dosage guidelines have yet to be established, clinical studies offer useful insight into the safe and effective handling of BPC-157 and other research peptides

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