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Obesity-associated variants within FTO form long-range functional connections with IRX3

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It functions as a master antioxidant and phase II detoxification cofactor, supporting both oxidative stress reduction and xenobiotic metabolism

504,505,506 GLP-1 enhances the insulin signaling pathway in the liver by activating the GLP-1R, especially through the phosphorylation of insulin receptor substrates and the activation of the PI3K/Akt signaling pathway, thereby increasing hepatic insulin sensitivity, facilitating glucose uptake and utilization, and reducing hepatic gluconeogenesis