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Increased p25 formation strongly correlated with enhanced apoptosis [69], indicating that while high CDK5/p35 promotes glioma tumorigenesis, intense CDK5 activity due to p25 formation results in cell death

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111 CCL1, the main ligand for CCR8, not only induces Treg migration but also promotes Treg differentiation and the expression of effector molecules such as CD39, IL-10, and granzymes