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Ensure the bottle is tightly closed and avoid storing it at temperatures above 20C to maintain its potency

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Crosstalk between apoptosis and autophagy in prostate epithelial cells under androgen deprivation

On the other hand, mTOR also participates in mitochondrial quality control and coordinates the degradation of defective organelles via autophagy and mitophagy

Using mouse embryonic fibroblasts (MEFs) and human malignant melanoma cells treated with active-site mTOR inhibitor (asTORi), was demonstrate that mTORC1 stimulates the translation of MTFP1 mediated by 4E-BP, and therefore the mTOR inhibition induces the phosphorylation of the DRP1 at Ser 637, this phosphorylation prevents it translocation to mitochondria, conversely, the pro-fission phosphorylation site of DRP1 at Ser 616 was decreased in asTORi treated cells