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Figure 4 Concurrently, the ATP deficiency resulting from hypoxia promotes the disintegration of organelles and cell membranes, producing substantial amounts of oxygen free radicals and inflammatory mediators, which further intensify cellular damage and apoptosis (80)

In Vitro Skin Irritation Test HaCaT keratinocytes were cultured in DMEM containing 10% fetal bovine serum and 1% penicillin/streptomycin and were maintained under 37 C with humidified 5% CO 2

Devalliere J, Dooley K, Hu Y, Kelangi SS, Uygun BE, Yarmush ML (2017) Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice

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Menopause amplifies the body's stress response