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The striatum and substantia nigra (SNc)-ventral tegmental area (VTA) regions were used for the stereological analysis, with specific cell markers such as tyrosine hydroxylase (TH), neuropeptide Y (NPY), and somatostatin (SST) quantified in these regions

Moreover, the use of drugs affecting mitochondria, where more than one-half of all ROS are generated, represents a suitable approach to induce oxidative stress and PCD in cancer cells 109 : gamitrinib, an inhibitor of heat shock protein 90 (HSP90), induces a dramatic collapse of mitochondria in prostate cancer cells 110 , while ARQ 501 (a quinone derivative) and STA-4783 (a copper chelator) increase ROS through leakage in the electron transport chain and have beneficial effects in patients with solid tumors and pancreatic adenocarcinoma 111

Int J Sports Nutr Exerc Metab 13:125151 Hogg N, Kalyanaraman B (1999) Nitric oxide and lipid peroxidation

Gene Expression Modulation Regulates genes involved in healing, regeneration, and longevity pathways

Hydroxocobalamin is also chemically incompatible with sodium thiosulfate and sodium nitrite and has been reported to be incompatible with ascorbic acid