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High drug concentrations and repeated instillation are commonly needed to improve the efficacy of drug administration through the local route, which may lead to poor patient compliance and numerous side effects [6]

Nevertheless, regardless of how prediction tools evolve, the clinical judgment of experienced physicians remains centralespecially in recognizing early warning signs such as SIRS and interpreting dynamic physiological changes, where clinical intuition remains irreplaceable

Studies also showed that a b GHK stimulates the level of p63 in human keratinocytes [13]

pseudomallei ), a Gram-negative environmental bacterium

10.1124/pr.111.004846 81 LiQ.YueY.ChenL.XuC.WangY.DuL.et al (2018)