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One thing to consider is that because ME/CFS is a severely disabling disease, many patients are house or bedbound and are unable to visit the clinics multiple times for follow-up analyses (39), even though these very severe cases are estimated to be around 25% of the ME/CFS cases (11, 39, 587)

Body calcium homeostasis Calcium is an important element for several biological processes, such as cell division and growth, blood coagulation, cardiovascular homeostasis, hormone responses, neural electrical activity, and bone formation [17, 18]

Lakhan SE, Vieira KF

Bones The knee joint involves 4 bones

Typical symptoms of chloride loss include dehydration, fatigue, shortness of breath, confusion, nausea, and vomiting (336)