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What it is / mechanism 5-Amino-1MQ is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide (consuming the methyl donor SAM) to form 1-methylnicotinamide, diverting nicotinamide away from the NAD+ salvage pathway

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This was because the drug did not significantly reduce weight in 536 subjects over the course of 24 weeks 2

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Improves energy metabolism in cells, contributing to enhanced vitality