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Therefore, elucidating the molecular mechanisms underlying glial contributions to ALS pathogenesis is crucial for advancing our knowledge of the disease and the development of targeted therapeutic strategies

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An example is GdW@CS polyoxometalate nanospheres, which combine radiosensitization capabilities with GSH depletion [86]

13 Future directions Future advances in GSH-responsive nanomedicine should focus on clinically relevant development rather than proof of concept designs