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Several studies have demonstrated that the inhibition of glutamate uptake can decrease tumor growth

ESCC-related metabolomic alterations in serum, urine and cancer tissues In addition to genetic and proteomic alterations, ESCC development is in association with cellular metabolic alterations that can give discernment into disease pathogenesis ( Table 2 ), indicating a potential network of metabolic pathway disturbances, such as TCA cycle, glycolysis, gluconeogenesis, glutaminolysis, amino acid metabolism, one-carbon unit metabolism, etc ( Figure 6 )

10.1016/j.freeradbiomed.2018.05.066 Free Radical

Malone, B

HR, 0.73