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D.AhlesT.et al

It can be an essential tool for patients dealing with leaky gut, IBS, or other systemic inflammation , as it helps re-establish the tight junctions of the intestinal wall

For instance, manuka honey restored the ability of metastatic colorectal cancer first-line drug 5-fluorouracil to abrogate resistance to apoptosis of cancer stem-like cells derived from the HCT-116 colon adenocarcinoma cell line by a pleiotropic mechanism involving the downregulation of IGF-1, IGF-2, IGF-1R, as well as other inhibitors of apoptosis, such as: inhibitors of apoptosis protein (IAP) family members survivin, livin, and XIAP

In addition, mice were intraperitoneally injected with 20 mg/kg DDP once at day 1 for survival analysis