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Upon binding to its ligands, PD-1 inhibits T cell function, reduces T cell proliferation, and promotes immune tolerance [108]

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As disease onset neared, microglia expressed increased chemokine (CC motif) ligand 2 and other chemotaxis-associated molecules, which are involved in the recruitment of monocytes to the CNS by spinal cordderived microglia

Platelet hyperactivity, increased prothrombotic coagulation factor activity, and impaired fibrinolysis are the main causes of an elevated thrombotic tendency in the context of low-grade chronic inflammation