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Nicotinamide adenine dinucleotide phosphate (NADPH) donates the electrons in both of these steps via a flavoprotein reductase

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Rhamnetin effectively blocks this process by inhibiting ATM-mediated phosphorylation at Thr68 and preventing Chk2 autophosphorylation at multiple sites, thus inhibiting the phosphorylation of key DNA repair proteins like p53 [53, 57]

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