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BDNF is known to play a fundamental role in survival and differentiation of selected neuronal populations during development and in the maintenance and plasticity of neuronal networks during adulthood 6,7

In addition, recent exploratory studies have found increased serum BDNF levels following holistic neuro-rehabilitative approaches, including computer-assisted cognitive enhancement in schizophrenia 20 , aerobic exercise in stroke 21 and mindfulness clinical trials in bipolar-disorder 22

Qiong Wang and Enchao Zhou conceived the study, participated in its design and coordination, and assisted in manuscript preparation

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LY3437943, a novel triple GIP, GLP-1 and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial