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MRTX849 (adagrasib) The ongoing clinical study of MRTX849 also offers hope for the successful targeting of KRAS (G12C) proteins 132

These mechanisms do not operate in isolation but rather form a self-amplifying vicious cycle: mitochondrial damage exacerbates OS and promotes pathological -syn aggregation

[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Schmidt M.E., Liebowitz M.R., Stein M.B., Grunfeld J., Van Hove I., Simmons W.K., Van Der Ark P., Palmer J.A., Saad Z.S., Pemberton D.J., et al

However, various drugs are still in the research stage and in the future, clinical attention should not only be paid to the efficacy and safety of such drugs, but also need to further evaluate the effects of combining drugs with different mechanisms, so as to ultimately provide patients with a reasonable individualized medication plan (Fig

Leber, D