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[15] After consumption of food containing 5% mustard seed, researchers found that mustard seed could increase endogenous antioxidant activity (SOD, catalase, and GSHpx) and reduce inflammatory cytokines (NFB, IFN, IL17, and IL22)

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The nonoperative treatment of KOA mainly includes anti-inflammatory drugs and biologics, such as non-steroidal anti-inflammatory drugs (NSAIDs), hyaluronic acid, glucocorticoids, diacrine, and chondroitin sulfate [7]