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A., Pica, N., Monuteaux, M

46,335 High levels of IDO, the enzyme involved in the catabolism of tryptophan, have been detected in many types of tumors associated with poor response

The metabolism of starch and sucrose (15 KOs), was also reduced in the AcM groups ( PYG , sucrose phosphorylase , GBE1 , glgA , UGP2 , glgC , malZ , INV , 6-phospho-beta-glucosidase , pgmB , celA , celB , scrA , bglX and inuJ ), together with the depletion of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), and with the biosynthesis of cofactors (31 KOs), including those involved in the metabolism of vitamins, such as thiamine ( adk , thiD , thiI and iscS ), riboflavin ( ribF ), pantothenate ( coaA , coaBC and coaE ), pyridoxine ( pdxK ) and folate ( DHFR , folC , folD , fhs , glyA and metK )

He reports that most vegans show adequate B12 levels to make clinical deficiency unlikely, but they may show restricted activity of B12-related enzymes, leading to elevated homocysteine levels, which has been linked to increased risk of heart disease and stroke

Boxer, L