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Abstract Serine hydrolases have important roles in signaling and human metabolism, yet little is known about their functions in gut commensal bacteria

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However, many of these supplements are still under investigation, with mixed results highlighting the need for high-quality research

2 Periodontitis shapes the oral microbiota and metabolite profiles influencing the oral-gut axis The oral bacteria of periodontitis patients exhibit greater diversity, with up to 10 bacterial genera dominating the condition (Liu et al., 2023)

It was shown that BDMC significantly reduced the levels of pro-inflammatory cytokines IL-6, IL-1, TNF-, and MCP-1 in LPS-induced RAW264.7 cells and that this anti-inflammatory effect is associated with inhibition of the activation of the PI3K/Akt signaling pathway ( Siraitia grosvenorii (Swingle) A.M.Lu and Z.Y.Zhang (Luohanguo) exerts an anti-inflammatory effect in the treatment of UC by modulating the AMPK-PI3K/Akt/mTOR signaling pathway