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found that in the mouse mode heme oxygenase 1 (HMOX-1), heat induced and regulated by early growth response factor 1 (EGR1), can mediate ferroptosis in KCs and cause liver injury [47]

AOD 9604 and Cardiovascular Health AOD 9604 has also been studied in cardiovascular research models, where its potential influence on lipid metabolism and vascular function has drawn attention

Extensive preclinical studies of NPI-001 support a strong mechanistic rationale for its use in RP, in which oxidative stress plays a known role

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11 However, the translational impact of these findings is limited, since only 1520% of patients are diagnosed at an early stage of disease