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ICC designed the review content, contributed to its writing and revised the conceptual contents until the final approval

Patients taking metformin do not necessarily need to take vitamin B12 supplementation

Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author

The amino acids in B complex injections, particularly inositol and methionine, help regulate appetite and enhance fat metabolism

Patient lifestyle, disease history, and medications can provide clues to the cause of B12 deficiency