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Enzyme replacement therapy for lysosomal diseases: Lessons from 20 years of experience and remaining challenges

SAMe is produced via the enzyme methionine adenosyltransferase (MAT) (Figure 1), which depending on the tissue, corresponds to three distinct forms: MAT I and MAT III, codified by the gene MAT1A , and MAT II, encoded by the gene MAT2A [6]

Nucleolin is also activated by some forms of PKC (409), thereby suggesting a plausible link between PKC-pathways and mRNA stability

10.1515/bc.2006.166 Biol

However, it is important to emphasize the fact that the skin is the only organ exposed to the external environment, especially areas such as the face, neck, hands, and arms, which reflect both chronological and photoaging [9]