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Another example might be the mutagenesis of a single codon position (i.e

Identification and characterization of a novel snat2 (slc38a2) inhibitor reveals synergy with glucose transport inhibition in cancer cells

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Volatiles were then evaporated under reduced pressure and the crude residue was dry-loaded and purified by chromatography on silica gel (DCM/MeOH gradient from 99:1 to 85:15) to afford 809 mg (83%) of title compound as a white solid