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Nanobiotech 20 (1), 230

Currently, treatments based on copper metabolism in cardiovascular disease can encompass a wide range of options, including copper chelating agents [such as triethylenetetramine (TETA), tetrathiomolybdate (TTM) and disodium ethylene diamine tetraacetic acid (EDTA)], small-molecule inhibitors of copper chaperone proteins (such as DCAL50), copper ion carriers and natural antidote agents (Table II)

Phenolic chemicals contained in these mushrooms (such as gallic acid, ferulic acid, and caffeic acid) have an important role in carcinogenesis prevention by reducing free radical formation and altering signaling pathways involved in cell proliferation and death

The uptake of GSH (or GSSG) could be through a specific transportersuch as a homologue of CydDC, which is an ATPbinding cassette (ABC)type transporter that has recently been identified to export GSH and cysteine specifically to the periplasm of Escherichia coli (Pittman et al , 2005)