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Limitations in the present study include statistical power

Pruritus characteristic of cirrhosis predominantly manifests as a central phenomenon, purportedly stemming from augmented release of -endorphin, Met-enkephalin, and endomorphin-1,2, which stimulate -receptors within nerve tissues

An analysis of the HPS2-THRIVE trial (see Cardiovascular disease), using data from 17,374 participants without type 2 diabetes at baseline, found a significantly higher proportion of newly diagnosed cases among those randomized to nicotinic acid/laropiprant than to placebo (5.7% versus 4.3%) over a 3.9 year-period (95)

Hazens team compared the impact of daily oral carnitine supplements on omnivores versus vegetarians/vegans

Blood 126 (23), 3059