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On multivariate analysis, poor differentiation (HR=1.991, 95% CI 1.633-2.427), macrovascular invasion(HR=2.558, 95% CI 1.875-3.489), lymph node involvement( HR=1.574, 95% CI 1.061-2.334) had a higher hazard of mortality

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There are a number of other topical agents that also work to combat hyperpigmentation via tyrosinase inhibition, antioxidation, or a combination of both (Table 1), that may be incorporated into a patients lightening regimen as alternatives or adjuncts to HQ or topical retinoids, when circumstances necessitate