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Studies have shown that glutamate levels in frontal cortex samples from autopsied patients with severe depression are increased, and antidepressants can restore normal glutamate levels

Glycemic category (normoglycemia, prediabetes or type 2 diabetes) was determined by investigators on the basis of available information (for example, medical records, concomitant medication, and blood glucose variables) and in accordance with American Diabetes Association criteria 30 , which for prediabetes includes fasting plasma glucose levels of 100 mg dl 1 (5.6 mmol l 1 ) to 125 mg dl 1 (6.9 mmol l 1 ) or HbA 1c levels of 5.76.4% (3947 mmol l 1 ), and for type 2 diabetes includes fasting plasma glucose levels of 126 mg dl 1 (7.0 mmol l 1 ) or HbA 1c levels 6.5% (48 mmol l 1 )

Food Sci Nutr 2020:46964707

The data shows that overweight and obese individuals tend to lose more weight with L-carnitine [11]