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In the slides of the brain tissue of the DM + MET group, minor degeneration and slight necrosis in neurons and minor hyperemia in arteries were noted

The activation of IKK by TRAF6 is achieved through the synthesis of lysine-63 (K63)-linked polyubiquitin chains catalyzed by the ubiquitin ligases Ubc13 and Uev1A, and the TAK1/TAB1/TAB2 protein kinase complex phosphorylates and activates IKK with the assistance of the polyubiquitin chains

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Biomed Pharmacother 114:108786 Zhang M et al (2023) Artesunate inhibits airway remodeling in asthma via the MAPK signaling pathway

In a double-blind clinical study, rutin has been shown to increase skin elasticity and reduce wrinkles length, area, and number when applied to the skin of subjects aged 3050 (26)