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While the clinical diagnosis of PD is based on the presence of defining motor features of bradykinesia, rest tremor and rigidity, additional motor symptoms like freezing of gait, postural instability, falls, dysarthria and dysphagia are key drivers of disability in advanced disease [3]

Secondly, the large surface area/volume ratio allows it to be utilized as a drug carrier to deliver drugs (Lv et al., 2021), genes (Mei et al., 2019), and other therapeutic molecules (Wang Y

doi: 10.1007/s00284-020-02243-5 184 SomashekaraiahRShruthiBDeepthiBVSreenivasaMY

Biomacromolecules 13, 952962