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CD47, sometimes referred to as the do not eat me signal, operates by binding to signal regulatory protein (SIRP) on macrophages, thereby preventing phagocytosis (1, 2)

392,393 Iron accumulates in the parenchymal cells of various organs in HH patients, generating ROS through the Fenton reaction, resulting in ferroptosis and several serious chronic complications, including heart disease, diabetes, and cirrhosis