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And there are meaningful, evidence-informed approaches to addressing them

Transitioning from preclinical to human trials is a major step in drug development, and healthy volunteers play a key role in ensuring that investigational drugs meet safety standards before they are tested in patients

Mudgal and coworkers demonstrated that in Swiss mice treated with LPS, a one-week treatment with a low dose of caffeine and a low dose of caffeic acid produced anxiolytic effects in the OFT and DLB, antidepressant effects in OFT and DLB, and anti-inflammatory effects with reduction of IL-6 and TNF-alpha in serum and brain [34]

In addition, earlier studies have shown that the interaction of rutin with ascorbic acid leads to an increase in the reducing properties of ascorbic acid, which is expressed by a decrease in xanthine oxidase activity, responsible for the cytosol production of superoxide anion [74]

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