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It was reported that metabolic activation of numerous other flavonoids was involved in or aggravated their toxicities (Table 1)

GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models

Our randomized clinical trial found a significant improvement in gait speed in older adults supplemented with GlyNAC

However, there are only a few studies related to the treatment of PF using MMDD, primarily focusing on in vivo experiments

Together, these findings depict a state of oxygen hypersensitivity in mitochondrial dysfunction, suggesting that oxygen metabolism is an important determinant of prognosis in mitochondrial disease and may play a role in its pathogenesis (Jain et al., 2016)