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In the mitochondrial matrix, reducing equivalent from the NADH generated from the fuel oxidation process can also be directly transferred to NADP + by the nicotinamide nucleotide transhydrogenase (NNT) to generate NADPH, therefore coupling the production of reducing power for oxidative phosphorylation metabolism (OXPHOS) and antioxidant systems (Figure 1)

Folate tolerance varies Folic acid, folinic acid and methylfolate may help selected patients but may worsen anxiety, agitation or sleep in susceptible undermethylators

The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiological forms of iron, or to a lesser extent to transferrin

Chem Cent J