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Also, in the experiments on human breast cancer cells, Won and Seo found that the inactivation of PI3K/Akt/mTORC1 signaling pathway promotes the expression of caspases and Bax leading to increased apoptosis [302]

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In patients with Alzheimers disease, research has found lower activity of the carnitine shuttle [12], lower activity of the enzymes responsible for creating acetyl-L-carnitine [13], and lower levels of acetyl carnitines [14]

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