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Description

Benton CB, Khan M, Gonzlez GN, Nazha A, Piao J, Ning J, Aung FM, Jabbour EJ, Kadia T, Borthakur G , Ravandi F, Komrokji RS, Steensma DP, DeZern AE, Roboz GJ, Sekeres MA, Andreeff M, Kantarjian HM, Garcia-Manero G

doi:10.1007/s00726-003-0012-1

10.1126/scitranslmed.3004404 Sci Transl Med

Cyt C forms the apoptosome complex with apoptotic protease activating factor-1 (APAF-1), thereby activating caspase-9, which subsequently cleaves effector caspases (caspase-3, -7, and -6) to execute apoptosis