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It is under investigation in preclinical and clinical studies on overweight, obesity, and metabolic disorders, where researchers have examined its effects on body weight and energy intake, including when combined with GLP 1 receptor agonists such as semaglutide, but it is not an approved therapy

The scientific picture, however, is far more complicated, and far more cautious

10.1111/j.1476-5381.1990.tb14707.x 31 BarretoNezR.BlandL

Blood Pressure Reduction Moderate Research Analysis of REDEFINE 1 data published in Hypertension demonstrated that CagriSema produced significant systolic blood pressure reductions of 10.9 mmHg compared to placebo at 68 weeks

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