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In adult tissue repair research, that 5% is pharmacologically irrelevant

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Most events transient and mild-moderate

References Abdulghani AA, Sherr A, Shirin S et al (1998) Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study