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Yang, G., Zhao, K., Ju, Y., Mani, S., Cao, Q., Puukila, S

7,8 In the United States alone, the total economic burden of PD is estimated to be $52 billion annually and therapeutic surgery can cost up to $100,000 per person

SLN124, a GalNAc-siRNA conjugate targeting TMPRSS6, efficiently prevents iron overload in hereditary haemochromatosis type 1

dopamine projections into nucleus accumbens and surrounding ventrostriatal regions), the development of craving and drug-seeking is a learned response that is underpinned by neuroplastic changes (Box 2)

*Correspondence: Zhaohui Meng, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers