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Thus, PDK suppresses the metabolic shift from glycolysis to the TCA cycle by downregulating PDH, thereby reducing mitochondrial ROS production and suppressing cell death [24,25]

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Mol Pharmacol 72:2939 Shinojima N, Yokoyama T, Kondo Y, Kondo S (2007) Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy