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Vitamin C, Thioctic Acid

10.1016/S1474-4422(19)30356-4 Lancet Neurol

Vascular Effects Vascular effects include: Angiogenesis Promotion Through VEGF and bFGF expression at 1 nM concentration Improved Blood Vessel Integrity Through collagen and elastin synthesis in vessel walls SPARC Protein Release Released during injury stimulates vessel growth and repair Enhanced Microcirculation Improved blood flow to peripheral tissues Anticoagulation Properties Demonstrated effects on blood clotting factors Restored Blood Flow To damaged tissues enhancing healing capacity Injectable Dosing Protocols and Administration Injectable GHK-Cu protocols typically use carefully calibrated dosing based on decades of research and clinical experience

No immediate change to prescribing, but signals a looming final decision (Category 1 or Category 3)

These findings strongly suggest that Celastrol possesses translational potential as a natural therapeutic agent for treating Cis-induced AKI in clinical settings