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Neurological symptoms represent a significant concern with B12 deficiency and may include: Paraesthesia (pins and needles) in the hands and feet Difficulty with balance and coordination Memory problems or cognitive changes Mood disturbances , including depression or irritability Glossitis (sore, red tongue) and mouth ulcers Haematological manifestations of B12 deficiency include megaloblastic anaemia , characterised by the production of abnormally large, immature red blood cells

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Studies have shown that supplemental L-Carnitine aids in reducing the blood sugar concentration by improving sensitivity to insulin

IGF-1 LR3 is a direct IGF-1 receptor agonist it bypasses the pituitary and liver entirely and acts directly on IGF-1 receptors in muscle, fat, and connective tissue

Transcriptomic analysis of the post-mortem brain of autistic individuals has shown that genes involved in synaptic function are downregulated [32, 33]