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LCINS is the eighth leading cause of cancer-related mortality in the USA and the fifth most common cause of cancer-related deaths worldwide

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In the early phase, compensatory responses may still counteract pathological alterations, thus masking therapeutic benefits, whereas in advanced stages these mechanisms are exhausted and disease manifestations become more stable and homogeneous, making treatment effects more evident

Indeed, increasing frataxin protein expression in FRDA patients to the levels found in carrier individuals that are asymptomatic is expected to provide a cure for the disease and stabilize disease progression