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If medical supervision and quality control are absent, the risk profile changes dramatically

278 It can be caused by diverse virus families ranging from DNA (i.e., HBV, EBV, HSV-1) to RNA viruses (i.e., HCV, RSV, DENV, Influenza, ZIKA, HIV)

Acknowledgements The authors would like to acknowledge Carlos Martn and Nacho Aguil for the critical reading of the manuscript

[42] They are highly transient, typically peaking during the initial 8-to-12-week dose-escalation phase before waning over time

Furthermore, clinical findings from a study involving 81 NSCLC patients treated solely with ICIs showed that those with MET amplification exhibited ICI resistance and had suboptimal PFS [123]