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Notably, Langley and colleagues reported that despite elevated plasma concentrations of individual antioxidants like ascorbic acid, uric acid, and sulfhydryl groups compared to healthy controls, the CF patients exhibited a significantly reduced TRAP (Langley et al., 1993)

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The mice were euthanized through CO2 inhalation when the tumor volume surpassed 1500 mm or when the mice showed signs of serious weight loss, dreadful weakness, or Unhealed ulcers, indicating they were moribund