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High caffeine intake (more than 500 mg or about five cups of coffee per day) reduces the chance of pregnancy by an estimated 45%

Thus, chemotherapeutic approaches to blocking DNA replication through disruption of disulfide reductase pathways will need to be cognizant of the potentially complete functional redundancy of the GSH and Trx pathways in animal systems, and sensitive to the various other physiological roles these pathways play in normal homeostatic and stress-response pathways

Neuron 103, 627641.e7

This creates an elevated TIMP to MMP ratio that correlates with collagen and elastin synthesis stimulation

Without that data, we simply don't have a complete picture of its side effects, optimal dosing, or long-term health impacts in humans